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Updated: Jul 16, 2026

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
Published on: November 8, 2018
[Status epilepticus and gatifloxacin]
S Koussa1, S Hage Chahine, A Zoghbi
1Service de Neurologie, Hôpital Hôtel-Dieu de France, Université Saint-Joseph, Beyrouth, Liban. koussalam@hotmail.com
Introduction:
The epileptogenic potential of quinolones differs from one product to the other. The rare epileptic seizures induced by gatifloxacin were seen with the intravenous route.
Patients:
We report two old ladies presenting with generalized status epilepticus after being treated orally with normal doses of gatifloxacin, with a good recovery. Past medical history of convulsion was the only factor found. Brain MR imaging was unremarkable. In one patient, EEG showed continuous bilateral paroxysmal discharges, predominantly frontal.
Conclusion:
Caution is warranted when using quinolones in elderly patients, especially those suffering from epilepsy.
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