Related Experiment Video

Updated: Jul 16, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

[Cerebral amyloid angiopathy]

J A Roch1, M Hermier, A Jouvet

  • 1Unité Cérébrovasculaire, Pr P Trouillas, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Bron.

Revue Neurologique
|February 17, 2007
PubMed

Insights

Cerebral amyloid angiopathy (CAA) involves amyloid protein buildup in brain blood vessels, leading to hemorrhage and cognitive issues, especially in older adults. This review covers CAA

Area of Science:

  • Neurology
  • Pathology
  • Radiology

Context:

  • Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder.
  • Amyloid protein deposition occurs in leptomeningeal vessels.
  • CAA is a significant factor in elderly cerebral hemorrhage, particularly after hypertension.

Purpose:

  • To review epidemiological data in CAA.
  • To review pathophysiological data in CAA.
  • To review clinical and MRI imaging data in CAA.

Summary:

  • CAA is characterized by cerebrovascular amyloid protein deposition.
  • Associated proteins include amyloid beta, cystatin C, transthyretin, gelsolin, and prion protein.
  • CAA contributes to cerebral hemorrhage, cognitive impairment, and transient neurological symptoms.

Impact:

  • Provides a comprehensive overview of CAA.
  • Highlights the role of CAA in cerebrovascular disorders.
  • Emphasizes the clinical and imaging aspects of CAA.

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