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Modified lymphocyte response to mitogens induced by the lipopeptide fragment derived from Mycobacterium avium
S K Tassell1, M Pourshafie, E L Wright
1Department of Microbiology and Immunology, Texas College of Osteopathic Medicine, Fort Worth 76107-2690.
Infection and Immunity
|February 1, 1992
Abstract:
The beta-elimination procedure was used to obtain two major fragments of Mycobacterium avium glycopeptidolipid antigens. The lipopeptide fragment, not the oligosaccharide, diminished the mitogen-induced blastogenic response of spleen cells at concentrations lower than those which affected viability. Electron microscopy revealed an internalization of lipopeptide and disruption of intracellular organization.