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Related Experiment Videos

Stromal acidosis affects corneal hydration control.

S R Cohen1, K A Polse, R J Brand

  • 1Morton D. Sarver Laboratory for Cornea and Contact Lens Research, School of Optometry, University of California, Berkeley.

Investigative Ophthalmology & Visual Science
|January 1, 1992
PubMed
Summary

Corneal acidosis, induced by low pH, may slow down corneal swelling recovery. This study monitored corneal thickness changes under normal and low pH conditions to investigate this effect.

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Area of Science:

  • Ophthalmology
  • Corneal Physiology
  • Contact Lens Research

Background:

  • Corneal hydration control is vital for maintaining corneal clarity.
  • Contact lens wear can induce corneal swelling and alter corneal pH.
  • A slower initial recovery phase in corneal thickness suggests a potential link between stromal acidosis and deswelling.

Purpose of the Study:

  • To investigate the effect of corneal acidosis on corneal hydration control.
  • To determine if reduced corneal pH retards the corneal deswelling process.

Main Methods:

  • Corneal recovery was monitored under normal (air) and low pH (7% CO2) conditions.
  • Corneal pH was assessed using fluorescence intensity (FI) ratios.
  • Open-eye steady-state (OESS) corneal thickness was measured before and after exposure.

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Main Results:

  • Exposure to 7% CO2 significantly reduced corneal pH (approx. 7.25) compared to air (approx. 7.50).
  • Reduced pH conditions did not substantially affect open-eye steady-state corneal thickness.
  • Corneal thickness changes were similar between normal and low pH exposures.

Conclusions:

  • Stromal acidosis does not appear to significantly retard corneal deswelling.
  • Corneal hydration control mechanisms are robust and not significantly impacted by moderate pH changes.
  • Further research may be needed to fully elucidate the complex interplay between corneal pH and hydration.