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Updated: Jul 16, 2026
10:24
Quantitation of Endothelial Cell Adhesiveness In Vitro
Published on: June 18, 2015
Endothelial cell adhesion molecules and cancer progression
Hanako Kobayashi1, Kimberly C Boelte, P Charles Lin
1Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Current Medicinal Chemistry
|February 20, 2007
Summary
Cell adhesion molecules (CAMs) facilitate leukocyte recruitment during inflammation and cancer cell metastasis. Understanding CAMs in cancer extravasation offers insights into tumor spread and potential anti-inflammatory therapies.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- Cell adhesion molecules (CAMs) like ICAM-1, VCAM-1, E-selectin, and P-selectin are crucial for leukocyte recruitment in inflammation.
- Circulating cancer cells share extravasation mechanisms with inflammatory cells, involving adhesion to the vascular endothelium.
Purpose of the Study:
- To review the role of CAMs in the extravasation of circulating cancer cells.
- To explore the connection between inflammation, tumorigenesis, and cancer metastasis.
Main Methods:
- Literature review focusing on cell adhesion molecules and cancer cell metastasis.
- Analysis of shared mechanisms between inflammatory cell recruitment and cancer cell extravasation.
Main Results:
- CAMs mediate leukocyte and cancer cell adhesion to endothelial cells.
- Sialyl Lewis (a/x) antigens on cancer cells bind to E-selectin, facilitating extravasation.
- The shared extravasation process links inflammation to tumorigenesis and suggests therapeutic potential for anti-inflammatory drugs.
Conclusions:
- CAMs play a critical role in cancer cell extravasation, a key step in metastasis.
- Understanding CAM involvement in the tumor microenvironment is vital for cancer research.
- Targeting CAMs or related pathways may offer novel therapeutic strategies for cancer treatment.
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