Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

beta-Barrel membrane bacterial proteins: structure, function, assembly and interaction with lipids.

Stefania Galdiero1, Massimiliano Galdiero, Carlo Pedone

  • 1Department of Biological Sciences, Division of Biostructures, University of Naples Federico II, CNR, Naples, Italy. sgaldier@unina.it

Current Protein & Peptide Science
|February 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting the fusion machinery of Peste des petits ruminants virus: design and in vitro characterization of an HRC-derived antiviral peptide.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Report from the 9th Italian Society for Virology (SIV-ISV) 2025 Annual Meeting.

Viruses·2026
Same author

Toscana Virus Diagnosis via a Point-of-Care Tool Based on Disposable Optical Fiber Biosensors.

Analytical chemistry·2026
Same author

Association between <i>Staphylococcus aureus</i> colonization and clinical improvement in pediatric atopic dermatitis treated with dupilumab: a pilot study.

Frontiers in medicine·2026
Same author

Gellan Gum/Alginate Films Containing Biogenic <i>uva ursi</i> Silver Nanoparticles: Analytical Characterization and Antiviral Activity Against HSV-1.

Molecules (Basel, Switzerland)·2026
Same author

Design and Characterization of an HRC-Derived Peptide Inhibitor of Canine Coronavirus Spike-Mediated Fusion.

Pathogens (Basel, Switzerland)·2026
Same journal

Exploring Neurological Disorder Therapeutics: The Progress and Future Prospects of Proteins and Peptides Derived from Blue Foods.

Current protein & peptide science·2026
Same journal

Significance of Proteomics in Cancer: Current Approaches and Trends in Biomarker Discovery.

Current protein & peptide science·2026
Same journal

Therapeutic Peptides as Targeting Vectors and Smart Therapeutics: Emerging Trends and Future Perspectives.

Current protein & peptide science·2026
Same journal

Innovative Protein Nanostructures and Hybrid Systems for Enhanced Encapsulation and Controlled Delivery of Bioactive Agents.

Current protein & peptide science·2026
Same journal

Nanotherapeutic Interventions in Diabetic Wound Healing: Biomarker- Guided Mechanisms and Translational Prospects.

Current protein & peptide science·2026
Same journal

Recent developments in intein-mediated protein splicing and their applications in bioengineering.

Current protein & peptide science·2026
See all related articles

Membrane proteins are challenging to study, but new insights reveal alpha-helical and beta-barrel structures. Understanding their lipid interactions is key to protein folding and function.

Area of Science:

  • Structural biology
  • Biochemistry
  • Membrane protein research

Background:

  • Membrane proteins constitute a third of all proteins but are underrepresented in 3D structure databases.
  • Alpha-helical and beta-sheet motifs are common, with specific locations and functions.
  • Beta-barrels are found in bacterial and mitochondrial outer membranes and form toxin channels.

Purpose of the Study:

  • To highlight the challenges and recent advances in membrane protein structural biology.
  • To emphasize the importance of understanding protein-lipid interactions for membrane protein function.
  • To discuss the structural diversity and functional versatility of beta-barrel motifs.

Main Methods:

  • X-ray crystallography
  • Electron microscopy

Related Experiment Videos

  • Structural analysis of membrane proteins

    • Main Results:

    • Identified alpha-helical bundles in receptors and ion channels.
    • Characterized beta-barrels in bacterial and mitochondrial membranes, including toxin channels.
    • Noted limited structural data on protein-lipid interactions despite their importance.

    Conclusions:

    • Membrane protein structures are diverse, with distinct motifs correlating to cellular location.
    • Beta-barrels offer a versatile scaffold with variations in gating and substrate selectivity.
    • Further research is needed to elucidate the molecular mechanisms of protein-lipid interactions for folding and function.