[Comparative study of two preservation solutions in the initial function after bilateral human lung transplantation]

Area of Science:

• Cardiology and Thoracic Surgery
• Transplantation Medicine
• Critical Care Medicine

Background:

• Lung transplantation is a life-saving procedure for end-stage lung disease.
• Preservation solutions are critical for maintaining graft viability and function.
• Euro-Collins (EC) and Perfadex (P) are commonly used preservation solutions with differing compositions.

Purpose of the Study:

• To compare the efficacy of Euro-Collins (EC) and Perfadex (P) preservation solutions on early pulmonary graft function in human lung transplant recipients.
• To evaluate the impact of preservation solutions on graft dysfunction, intensive care unit (ICU) stay, mechanical ventilation duration, and 30-day mortality.

Main Methods:

• Retrospective study involving 79 patients undergoing bilateral lung transplantation.
• Grafts were preserved using either EC (n=23) or P (n=56).
• Pulmonary function (PaO2/FiO2 ratio), graft dysfunction, ICU stay, mechanical ventilation time, and 30-day mortality were assessed.

Main Results:

• The PaO2/FiO2 ratio was significantly higher in the Perfadex (P) group compared to the Euro-Collins (EC) group on ICU admission and at 12 hours post-transplant.
• Incidence of graft dysfunction was significantly lower in the P group than in the EC group.
• No significant differences were observed in 30-day mortality, ICU stay, or mechanical ventilation duration between the groups.

Conclusions:

• Perfade (P) preservation solution is associated with superior early pulmonary graft function following lung transplantation compared to Euro-Collins (EC).
• Using Perfadex (P) for pulmonary graft preservation may decrease the incidence of early graft dysfunction.
• Further research may explore long-term outcomes and cost-effectiveness of different preservation solutions.