Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statins enhance circulating vitamin E.

Roberto Cangemi, Lorenzo Loffredo, Roberto Carnevale

    International Journal of Cardiology
    |February 20, 2007
    PubMed
    Summary

    Statins may improve antioxidant status in patients with metabolic syndrome. This study found statin users had higher vitamin E and lower oxidative stress markers like 8-hydroxy-2-deoxyguanosine (8-OHdG).

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation.

    European journal of clinical investigation·2026
    Same author

    Age-Related Platelet Cox-1 Upregulation in Atrial Fibrillation.

    International journal of molecular sciences·2026
    Same author

    Pharmacological rhythm control strategy and outcomes in the oldest atrial fibrillation patients: an analysis of the nationwide Italian START registry.

    Age and ageing·2026
    Same author

    Matrix metalloproteinase 2 (MMP-2) and cardiovascular events in atrial fibrillation patients: A nested case control study from the ATHERO-AF cohort.

    Thrombosis research·2026
    Same author

    Age-related efficacy of aspirin in secondary prevention of coronary artery disease: START-ANTIPLATELET registry and meta-analysis of randomized trials.

    The American journal of medicine·2026
    Same author

    Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin-Nox2 interaction in cardioprotection.

    Frontiers in nutrition·2026

    Area of Science:

    • Biochemistry
    • Cardiology
    • Metabolic Syndrome Research

    Background:

    • Statins are known to reduce oxidative stress, but their impact on antioxidant status remains unclear.
    • This study investigated serum levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and vitamin E in metabolic syndrome patients.
    • A retrospective analysis compared patients treated with statins versus those not treated.

    Discussion:

    • Statin-treated patients exhibited significantly higher vitamin E levels (p=0.02).
    • Patients on statins also showed significantly lower serum 8-OHdG levels (p<0.01), indicating reduced oxidative stress.
    • A strong inverse correlation (r=-0.670, p<0.001) was found between oxidative stress markers and vitamin E levels.

    Key Insights:

    • Preliminary findings suggest statins enhance antioxidant status in metabolic syndrome patients.
    • The mechanism appears to involve the inhibition of oxidative stress by statins.
    • Vitamin E levels may serve as a biomarker for statin's effect on antioxidant capacity.

    Outlook:

    • Further prospective studies are warranted to confirm these findings.
    • Investigating the precise molecular mechanisms by which statins influence vitamin E and oxidative stress is crucial.
    • Exploring the clinical implications of enhanced antioxidant status in statin users could lead to new therapeutic strategies.

    Related Experiment Videos