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Relationship between left ventricle geometric patterns and lymphocyte DNA damage in patients with untreated essential

Mustafa Gur1, Ali Yildiz, Recep Demirbag

  • 1Harran University, Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey. drmugur@yahoo.com

Clinical Biochemistry
|February 20, 2007
PubMed

Insights

Hypertension (HT) patients show increased lymphocyte DNA damage, particularly with concentric hypertrophy. Oxidative stress, indicated by total antioxidant status (TAS), is linked to this DNA damage, not left ventricle geometry.

Area of Science:

  • Cardiology
  • Genetics
  • Oxidative Stress Research

Background:

  • Hypertension (HT) is a significant cardiovascular risk factor.
  • Left ventricle (LV) geometry changes are common in HT.
  • Lymphocyte DNA damage may serve as a biomarker for HT-related cellular damage.

Purpose of the Study:

  • To examine the relationship between distinct LV geometric patterns and lymphocyte DNA damage in hypertensive patients.
  • To assess the role of total antioxidant status (TAS) in this association.

Main Methods:

  • Study included 84 hypertensive patients and 24 healthy controls.
  • LV geometric patterns were classified based on LV mass index and relative wall thickness.
  • Lymphocyte DNA damage and plasma TAS levels were measured.

Main Results:

  • Hypertensive patients exhibited significantly higher lymphocyte DNA damage than controls (p=0.001).
  • Concentric hypertrophic LV geometry showed the greatest increase in DNA damage (p<0.001).
  • Lymphocyte DNA damage was independently correlated with TAS (beta=-0.444, p<0.001) but not LV geometry (p>0.05).

Conclusions:

  • Concentric hypertrophic LV geometry is associated with the most significant increase in lymphocyte DNA damage.
  • Elevated oxidative stress, suggested by lower TAS, may underlie the observed DNA damage in hypertensive patients.
Abstract

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