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Polymorphic variants of genes encoding main antioxidant enzymes and the risk of CL/P-affected pregnancies
Adrianna Mostowska1, Kamil K Hozyasz, Margarita Lianeri
1Department of Biochemistry and Molecular Biology, University of Medical Sciences in Poznan, Swiecickiego St 6, 60-781 Poznan, Poland. amostowska@wp.pl
Objective:
The study focused on the correlation between maternal polymorphisms of genes encoding antioxidant enzymes and the risk of having a child with CL/P in the Polish population.
Method:
PCR-RFLP analysis was used to analyze polymorphisms of MnSOD2 (c.47T>C), CAT (c.-330C>T) and GPX1 (c.599C>T) in mothers of children with CL/P and control mothers.
Results And Conclusion:
Polymorphic variants of genes for main antioxidant enzymes were determined not to be a maternal risk factor for having a child with CL/P in the investigated group of women.
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