Optimal design and experimental validation of synchronous, asynchronous and flow-modulated, simulated moving-bed...

Area of Science:

• Chemical Engineering
• Separation Science
• Chromatography

Background:

• Simulated moving-bed (SMB) chromatography is crucial for industrial separations.
• Optimizing SMB process parameters is key to enhancing separation efficiency.
• Novel configurations like asynchronous and flow-modulated SMB offer potential performance improvements.

Purpose of the Study:

• To experimentally and numerically evaluate asynchronous (Varicol) and flow-modulated (PowerFeed) SMB processes.
• To investigate the impact of operating parameters on these SMB schemes.
• To demonstrate performance enhancements achievable through optimized hybrid SMB configurations.

Main Methods:

• Utilized a single-column experimental setup for SMB process demonstration.
• Performed numerical simulations to model process performance.
• Optimized operating parameters for linear separation of two nucleosides.
• Employed a high-performance reversed-phase stationary phase.

Main Results:

• Demonstrated the experimental feasibility of Varicol and PowerFeed SMB schemes.
• Identified key operating parameters influencing process performance.
• Showcased significant performance enhancements with optimized hybrid SMB configurations.
• Achieved effective linear separation of nucleosides.

Conclusions:

• Asynchronous and flow-modulated SMB processes, individually and combined, offer viable and efficient separation solutions.
• Optimization of operating parameters is critical for maximizing SMB performance.
• The hybrid SMB approach provides a powerful strategy for enhanced separation of target compounds.