Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is the Immune System?01:38

What is the Immune System?

Overview
Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterizing the NIH Activity and Chronicity Indices in 2 Independent Lupus Nephritis Cohorts.

Kidney international reports·2026
Same author

Are the 2023 ACR/EULAR classification criteria a step forward in the management of antiphospholipid syndrome? A literature-based and clinical practice appraisal.

Autoimmunity reviews·2025
Same author

2023 ACR/EULAR classification criteria for antiphospholipid syndrome: more lights rise but shade remains.

RMD open·2025
Same author

Hughes syndrome: The discovery of the antiphospholipid syndrome.

Medicina clinica·2024
Same author

Lupus Nephritis Outcomes after Stopping Immunosuppression.

Journal of clinical medicine·2024
Same author

Combined rituximab and belimumab to treat recalcitrant epidermolysis bullosa aquisita associated with systemic lupus erythematosus.

The British journal of dermatology·2024

Related Experiment Video

Updated: Jul 1, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Systemic lupus erythematosus.

David P D'Cruz1, Munther A Khamashta, Graham R V Hughes

  • 1Lupus Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK. david.d'cruz@kcl.ac.uk

Lancet (London, England)
|February 20, 2007
PubMed
Summary

Systemic lupus erythematosus (SLE) is a complex autoimmune disease primarily affecting women. Recent advances cover epidemiology, genetics, organ-specific manifestations, and novel therapies like biological agents.

Area of Science:

  • Rheumatology and Immunology
  • Autoimmune Diseases
  • Connective Tissue Disorders

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune connective-tissue disorder.
  • It predominantly affects women, with variations across ethnic groups.
  • Diagnosis relies on clinical presentation and autoantibody detection.

Purpose of the Study:

  • To review recent advancements in SLE.
  • To cover key areas including epidemiology, genetics, and clinical manifestations.
  • To discuss emerging therapeutic strategies.

Main Methods:

  • Literature review and synthesis of current research.
  • Focus on epidemiology, genetics, and clinical aspects of SLE.
  • Evaluation of new treatment modalities.

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Related Experiment Videos

Last Updated: Jul 1, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Main Results:

  • SLE impacts multiple organ systems, including cardiovascular, renal (lupus nephritis), and central nervous system (CNS).
  • Antiphospholipid syndrome is a significant comorbidity.
  • Disease activity assessment and pregnancy-related issues are critical management aspects.

Conclusions:

  • Comprehensive understanding of SLE epidemiology and genetics is evolving.
  • Advances in understanding cardiovascular risks, nephritis, and CNS disease are crucial.
  • Novel therapies, including biological agents and mycophenolate mofetil, offer new treatment avenues for SLE management.