Related Experiment Video
Updated: Jul 16, 2026

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
Published on: February 27, 2018
Cumulative Exposure to General anesthesias and cognitive dysfunction at age 75 in the Vienna Transdanube Aging "VITA"
Peter Fischer1, Helene Wallner, Susanne Jungwirth
1Department of General Psychiatry, University Hospital for Psychiatry, Waehringer Guertel 18-20, A-1090 Vienna/Wien, Austria. Peter.Fischer@meduniwien.ac.at
Abstract:
Some reports have described general anesthesias as a risk factor for dementia in the elderly. The authors investigated whether the number of general anesthesias during a lifetime was associated with cognitive functioning in the community-based age cohort of a geographical area of Vienna. Out of 606 seventy-five-year-old subjects, 43 reported not having undergone anesthesia and 113 reported five or more anesthesias. The number of general anesthesias was not associated with extensive psychometric data. Cognitive dysfunction at age 75 was significantly associated with level of education, a history of major head trauma, and having lived in a rural environment during childhood.
Related Concept Videos
Stages of General Anesthesia
Pharmacodynamics in Geriatric Patients: Effects of Age
Cognitive Development During Adulthood
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Drug Dosing: Geriatric Patients
