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Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Systemic inflammatory mediators and bone homeostasis in intestinal failure.
Charlene Compher1, Michael Pazianas, Stephen Benedict
1University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania 19104-6096, USA. compherc@nursing.upenn.edu
JPEN. Journal of Parenteral and Enteral Nutrition
|February 20, 2007
Summary
Inflammation is linked to lower calcium levels and longer parenteral nutrition (PN) dependence in patients with intestinal failure. Further research is needed to understand the relationship between vitamin D deficiency and inflammation in this population.
Area of Science:
- Gastroenterology
- Endocrinology
- Immunology
Background:
- Patients with intestinal failure often exhibit a proinflammatory state.
- Metabolic bone disease is prevalent in this patient group.
- The relationship between inflammation and bone parameters in intestinal failure is not well understood.
Purpose of the Study:
- To investigate the association between inflammation and bone disease in patients with parenteral nutrition-dependent intestinal failure.
Main Methods:
- Assayed serum for inflammatory markers (IL-6, TNF-alpha, TNFR-I, TNFR-II, CRP) and lymphocyte proliferation in eight patients.
- Compared routine bone metabolism markers (vitamin D, PTH, calcium, phosphorus) with inflammatory markers using Pearson's correlation.
Main Results:
- Patients showed reduced 25-hydroxy vitamin D and elevated parathyroid hormone and alkaline phosphatase.
- Serum calcium negatively correlated with TNFR-II and TNF-alpha.
- Longer parenteral nutrition dependence was associated with inflammation and reduced T-helper cells.
Conclusions:
- Preliminary findings suggest a link between low calcium, prolonged parenteral nutrition, and inflammation in intestinal failure.
- The causal relationship between vitamin D deficiency and inflammation requires further investigation.
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