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Updated: Jul 16, 2026

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia

Published on: January 23, 2009

Stem cell use in critical limb ischemia.

R Kolvenbach¹, C Kreissig, E Ludwig

¹Department of Vascular Surgery and Endovascular Therapy, Augusta Hospital, Duesseldorf, Germany. kolvenbach@vkkd-kliniken.de

The Journal of Cardiovascular Surgery

|February 20, 2007

Summary

Stem cell therapy shows promise for vascular medicine, particularly using endothelial progenitor cells (EPCs) to repair blood vessels and treat tissue ischemia. Further research into combining stem cells with gene therapy could enhance treatment efficacy.

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Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

Published on: November 5, 2011

Area of Science:

Vascular Medicine
Regenerative Medicine
Cellular Therapy

Background:

Stem cell applications are rapidly evolving in vascular medicine.
Endothelial progenitor cells (EPCs) play a crucial role in vascular repair.
Critical ischemia presents a significant clinical challenge requiring novel therapeutic strategies.

Purpose of the Study:

To provide an overview of current stem cell applications in vascular medicine.
To discuss the role and therapeutic potential of endothelial progenitor cells (EPCs).
To evaluate different stem cell-based treatment approaches for critical ischemia.

Main Methods:

Review of current literature on stem cell use in vascular medicine.
Discussion of bone marrow-derived mononuclear cells for critical ischemia treatment.
Analysis of experience with purified CD133 and CD34 cells.
Consideration of gene therapy combined with stem cell injections.

Main Results:

Clinical and laboratory results from 15 patients with end-stage critical ischemia were analyzed.
Different stem cell treatment regimens (bone marrow mononuclear cells vs. purified CD133/CD34 cells) were compared.
The pros and cons of various treatment strategies were discussed.

Conclusions:

Despite ongoing questions, EPC-based therapies offer a promising outlook for tissue ischemia and blood vessel repair.
The combination of gene therapy and stem cell injections presents a potential future direction.
Findings have implications for the design of future clinical trials in vascular regeneration.