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Updated: Jul 16, 2026

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

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Published on: August 16, 2019

Antigen-specific immunotherapy for autoimmune diseases.

Kazuhiko Yamamoto¹, Akiko Okamoto, Keishi Fujio

¹University of Tokyo, Department of Allergy and Rheumatology, Graduate School of Medicine, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113, Japan. yamamoto-tky@umin.ac.jp

Expert Opinion on Biological Therapy

|February 21, 2007

Summary

T cell receptor gene transfer offers a novel approach for antigen-specific immunotherapy in autoimmune diseases. This method engineers a patient's own lymphocytes to target specific disease-related T cells, improving treatment efficacy and safety.

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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

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Published on: August 16, 2019

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

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Published on: November 8, 2016

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Published on: August 11, 2014

Area of Science:

Immunology
Gene Therapy
Autoimmune Diseases

Background:

Current autoimmune disease therapies have limitations.
Antigen-specific immunotherapy shows promise for targeted treatment with fewer side effects.
Existing strategies for manipulating antigen-specific T cells are insufficient.

Purpose of the Study:

To propose T cell receptor gene transfer as a viable strategy for antigen-specific immunotherapy.
To outline a method for engineering T cells for targeted autoimmune disease treatment.

Main Methods:

Identify disease-related, antigen-specific T cells in patients.
Isolate alpha and beta T cell receptor cDNAs from these T cells.
Transfer these genes into autologous lymphocytes for engineered T cell therapy.

Main Results:

The proposed method allows for the engineering of antigen-specific T cells.
Engineered cells can be further modified to express functional genes for immunotherapy.

Conclusions:

T cell receptor gene transfer represents a promising avenue for developing effective and safe antigen-specific immunotherapies.
This approach could overcome current limitations in manipulating T cells for autoimmune disease treatment.