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Updated: Jul 16, 2026

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
Published on: July 25, 2017
Human papillomavirus infection and primary fallopian tube carcinoma: a seroepidemiological study
1Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland. annika.riska@pp.inet.fi
Objective:
To evaluate the role of human papillomavirus (HPV) types 6, 11, 16, 18, 31 or 33 infection in primary fallopian tube carcinoma (PFTC).
Design:
A retrospective case-control study.
Setting:
Department of Obstetrics and Gynaecology, Helsinki University Hospital, Finland.
Population:
Seventy-eight consecutive women with PFTC diagnosed between 1985 and 2000 were studied. For each case, two healthy controls were selected.
Methods:
Serum immunoglobulin G antibodies to HPV types 6, 11, 16, 18, 31 and 33 were measured from women with PFTC and their healthy controls.
Main Outcome Measures:
Analysis of HPV 6, 11, 18, 31 and 33 seropositivity among women with PFTC and controls.
Results:
Seropositivity rates of non-oncogenic or oncogenic HPV types did not differ between cases and controls, odds ratios being 1.04-1.30 for oncogenic HPVs and 1.08-1.19 for non-oncogenic HPVs, similarly. We did not find any multiplicative joint effect in PFTC by antibodies to more than one oncogenic HPV type; neither did we find any antagonistic effect among women with antibodies to non-oncogenic and oncogenic HPV types.
Conclusions:
Our results do not suggest any link between PFTC and serological evidence for HPV infection.
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