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Practical issues drawn from the implementation of the integrated test for Down syndrome screening into routine
1Department of Fetal Medicine, Elizabeth Garret Anderson and Obstetric Hospital, University College Hospital, London, UK.
Abstract:
We have evaluated a cohort of women booked for antenatal care at University College London Hospitals. The uptake of screening was 64.4% and was significantly higher (73 versus 46%) in women who booked before 14 weeks. Of the women who booked before 14 weeks, 96.8% opted for the integrated test (IT). Overall, 5.3% failed to attend for the second blood test. The false-positive rate in the women who had the IT was 2.9%. All 11 cases of Down syndrome were detected prenatally. Our study is the first to evaluate implementation of the IT into routine clinical practice.
