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Practical issues drawn from the implementation of the integrated test for Down syndrome screening into routine

B Weisz1, P Pandya, L Chitty

  • 1Department of Fetal Medicine, Elizabeth Garret Anderson and Obstetric Hospital, University College Hospital, London, UK.

BJOG : an International Journal of Obstetrics and Gynaecology
|February 21, 2007
PubMed

We have evaluated a cohort of women booked for antenatal care at University College London Hospitals. The uptake of screening was 64.4% and was significantly higher (73 versus 46%) in women who booked before 14 weeks. Of the women who booked before 14 weeks, 96.8% opted for the integrated test (IT). Overall, 5.3% failed to attend for the second blood test. The false-positive rate in the women who had the IT was 2.9%. All 11 cases of Down syndrome were detected prenatally. Our study is the first to evaluate implementation of the IT into routine clinical practice.

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