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Mortality risk factors in sleep apnoea: a matched case-control study
Peretz Lavie1, Paula Herer, Lena Lavie
1Lloyd Rigler Sleep Apnea Research Laboratory, Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. plavie@tx.technion.ac.il
Journal of Sleep Research
|February 21, 2007
Summary
Mortality in sleep apnea is linked to obesity and co-morbidities like COPD, heart failure, and diabetes. Sleep apnea severity interacts with BMI and lung disease to impact survival.
Area of Science:
- Medical Research
- Pulmonology
- Epidemiology
Background:
- Sleep apnea syndrome is a known risk factor for increased mortality.
- The independent contribution of obesity and comorbidities to this mortality risk remains unclear.
Purpose of the Study:
- To investigate predictors of all-cause mortality in a large cohort of men diagnosed with sleep apnea.
- To determine if the association between sleep apnea and mortality is independent of obesity and co-morbidities.
Main Methods:
- A case-control study design was employed.
- 10,981 men diagnosed with sleep apnea via polysomnography were included.
- Multivariate analysis was used to identify mortality predictors and interactions.
Main Results:
- Mortality was associated with chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), diabetes mellitus (DM), and body mass index (BMI).
- Chronic upper airway problems were linked to improved survival.
- Interactions were observed between respiratory disturbance index, BMI, and COPD, influencing mortality.
Conclusions:
- All-cause mortality in sleep apnea patients is significantly associated with co-morbidities and obesity.
- The severity of sleep apnea impacts mortality, particularly through interactions with obesity and lung disease.
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01:24Sleep-Wake Cycles
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01:17Sleepwalking and Sleep Talking
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