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Updated: Jul 16, 2026
08:56
Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction
Published on: May 7, 2015
[Oxidative stress and oxygen status in ischemic stroke]
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|February 22, 2007
Summary
Ischemic stroke patients show reduced antioxidant system enzymes and increased lipid peroxidation early on. Decreased alkaline phosphatase activity predicts good functional recovery within 21 days.
Area of Science:
- Biochemistry
- Neuroscience
- Pathophysiology
Context:
- Ischemic stroke is a leading cause of disability.
- Understanding the acute phase pathophysiology is crucial for effective treatment.
- Dynamic assessment of metabolic and oxidative stress markers is needed.
Purpose:
- To dynamically assess oxygen status, antioxidant system enzymes (AOS), specific dehydrogenases (SDG, alpha-GPDH), alkaline phosphatase (AP), reduced glutathione (GSH), and lipid peroxidation products (PLPRTA) in acute ischemic stroke.
- To correlate these biochemical markers with stroke progression and functional recovery.
Summary:
- Patients with acute hemispheric ischemic stroke exhibited relative hyperoxia on days 1 and 3.
- Reduced AOS activity and increased PLPRTA were observed from day 1.
- SDG activity decreased, while alpha-GPDH activity significantly increased.
- A decline in leukocyte AP activity by day 7 correlated with good functional rehabilitation by day 21.
- Oxidative stress appears to stem from bioenergetic process disruption and reduced AOS activity.
Impact:
- Identifies early biochemical markers of oxidative stress in ischemic stroke.
- Suggests AP activity as a potential prognostic indicator for functional recovery.
- Provides insights into the interplay between bioenergetics, oxidative stress, and stroke outcomes.
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