A smoking cessation programme in HIV-infected individuals: a pilot study
Luigia Elzi1, David Spoerl, Jacqueline Voggensperger
1Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel.
Antiviral Therapy
|February 22, 2007
Summary
A smoking cessation program (SCP) for individuals with HIV significantly increased smoking abstinence rates at 12 months compared to controls. This intervention is feasible and should be encouraged to reduce cardiovascular disease (CVD) risk in this population.
Area of Science:
- Public Health
- Cardiology
- Infectious Diseases
Background:
- Antiretroviral therapy (ART) is linked to increased cardiovascular disease (CVD) risk.
- Smoking is the primary modifiable risk factor for CVD, particularly in individuals with HIV.
Purpose of the Study:
- To evaluate the effectiveness of a smoking cessation program (SCP) including counseling and nicotine replacement therapy in HIV-infected individuals.
- To assess the impact of smoking cessation on CVD morbidity and mortality in this population.
Main Methods:
- A prospective study evaluated an SCP intervention group (counseling and nicotine replacement therapy) against a control group not participating in the SCP.
- The primary endpoint was the smoking cessation rate at 12 months; secondary endpoints included CVD morbidity and mortality.
Main Results:
- The SCP achieved a 12-month smoking abstinence rate of 38% (13/34) compared to 7% (27/383) in the control group (OR 6.2).
- SCP participants had a higher 10-year CVD risk (11.2% vs. 8.5%).
- While two SCP participants had myocardial infarctions versus four controls, one control patient died of CVD.
Conclusions:
- Smoking cessation programs are feasible and beneficial for HIV-infected individuals.
- Further comparative trials are needed to confirm the long-term impact of smoking cessation on CVD outcomes in this population.
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