Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Focus on Fotemustine.

A De Rossi1, L Rossi, A Laudisi

  • 1Department of Neuroscience, University of Rome "Tor Vergata", Italy.

Journal of Experimental & Clinical Cancer Research : CR
|February 22, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain and Behavior in Persuasion: The Role of Affective-Cognitive Matching.

Psychophysiology·2025
Same author

Prognostic role and interaction of TERT promoter status, telomere length and MGMT promoter methylation in newly diagnosed IDH wild-type glioblastoma patients.

ESMO open·2023
Same author

Repair of Dental Restorations: A 10-year Retrospective Analysis of Clinical Data.

Operative dentistry·2022
Same author

IgG4-positive plasma cells are more often detected in chronic periapical lesions arising from permanent rather than primary teeth.

International endodontic journal·2020
Same author

Long-term clinical, virological and immunological outcomes following planned treatment interruption in HIV-infected children.

HIV medicine·2020
Same author

Fibroblast growth factor receptor 2 expression in apical periodontitis in mice.

International endodontic journal·2020
Same journal

Extracellular vesicle-mediated GALNT1/RPRD1A glycosylation axis drives immune escape and peritoneal metastasis in gastric cancer.

Journal of experimental & clinical cancer research : CR·2026
Same journal

NHE7-Driven endoplasmic reticulum stress signaling transmission promotes malignant progression of endometrial cancer via c-Fos/PRSS1/ERP27 axis.

Journal of experimental & clinical cancer research : CR·2026
Same journal

Correction: Nanovaccines with ferroptosis, necroptosis and STING-activation for synergistic immunotherapy.

Journal of experimental & clinical cancer research : CR·2026
Same journal

Adipocyte-rich microenvironment promotes TNBC progression through SIRT6-associated ACSL5 dysregulation and lipid storage-associated phenotypes.

Journal of experimental & clinical cancer research : CR·2026
Same journal

Correction: Copy number amplification-induced overexpression of lncRNA LOC101927668 facilitates colorectal cancer progression by recruiting hnRNPD to disrupt RBM47/p53/p21 signaling.

Journal of experimental & clinical cancer research : CR·2026
Same journal

Decoding glioblastoma evolution and heterogeneity through mechanistic modeling: implications for clinical translation.

Journal of experimental & clinical cancer research : CR·2026
See all related articles

Fotemustine, a nitrosourea alkylating agent, demonstrates antitumor activity and acceptable toxicity. Its potential role in treating hematological malignancies is suggested due to its mechanism and pharmacodynamic properties.

Area of Science:

  • Oncology
  • Pharmacology
  • Cancer Biology

Background:

  • Fotemustine is a cytotoxic alkylating agent from the nitrosourea family.
  • Its mechanism involves mono-functional/bi-functional DNA alkylation.
  • Drug resistance can arise from high levels of O6-methylguanine-DNA-methyltransferase (MGMT).

Purpose of the Study:

  • To review the antitumor activity, toxicity, and potential applications of Fotemustine.
  • To explore Fotemustine's suitability for hematological malignancies.

Main Methods:

  • Review of clinical trial data.
  • Analysis of Fotemustine's pharmacokinetic and pharmacodynamic properties.
  • Comparison with other alkylating agents like Temozolomide.

Related Experiment Videos

Main Results:

  • Fotemustine exhibits significant antitumor activity as a single agent and in combination therapies.
  • Its toxicity profile is generally acceptable.
  • The drug has been used for metastatic melanoma and brain tumors.

Conclusions:

  • Fotemustine shows promise for treating hematological malignancies, particularly acute refractory leukemia, based on its properties.
  • Further investigation into its role in blood cancers is warranted.