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Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding

H B Fleisig1, N I Orazio, H Liang

  • 1Department of Molecular Genetics, MD Anderson Cancer Center, Houston, TX 77030, USA.

Oncogene
|February 22, 2007
PubMed
Summary

Adenoviral oncoprotein E1B55K binds to sequence-specific single-stranded DNA-binding protein 2 (SSBP2), a potential acute myelogenous leukemia (AML) tumor suppressor. E1B55K sequesters SSBP2 into aggresomes, but does not degrade it.

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