Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response prediction after neoadjuvant chemoradiotherapy in esophageal cancer using FDG-PET and multiparametric MRI: A prospective multicenter study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Non-cell-autonomous mechanisms of tumor initiation and relapse by chromosomal instability.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A 64-Year-Old Patient With T1b Esophageal Adenocarcinoma: What Treatment Options Do We Have?

Gastroenterology·2026
Same author

Mapping the genetic landscape of hereditary diffuse-type gastric cancer progression.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·2026
Same author

WNT7B drives a program for pancreatic cancer subtype switching and progression.

iScience·2026
Same author

Pancreatic cancer risk and survival in patients with Lynch syndrome: a nationwide Dutch cohort study.

EClinicalMedicine·2026

Related Experiment Video

Updated: Jul 16, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Gastrointestinal polyposis syndromes.

Lodewijk A A Brosens1, W Arnout van Hattem, Marnix Jansen

  • 1Department of Pathology, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. l.a.brosens@amc.uva.nl

Current Molecular Medicine
|February 22, 2007
PubMed
Summary

Hereditary gastrointestinal polyposis syndromes, including familial adenomatous polyposis (FAP), juvenile polyposis (JP), and Peutz-Jeghers syndrome (PJS), offer crucial insights into colorectal cancer development. Understanding their genetics and clinical features aids in cancer research and prevention.

More Related Videos

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Related Experiment Videos

Last Updated: Jul 16, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Area of Science:

  • Oncology
  • Gastroenterology
  • Medical Genetics

Background:

  • Colorectal cancer incidence is increasing in Western societies, representing a significant cause of cancer-related mortality.
  • Hereditary gastrointestinal polyposis syndromes serve as valuable models for studying cancer initiation and progression.
  • Research into these rare syndromes has yielded significant insights into the molecular genetic basis of cancer.

Purpose of the Study:

  • To review the genetics of common hereditary gastrointestinal polyposis syndromes.
  • To describe the clinical manifestations associated with these syndromes.
  • To highlight the role of these syndromes in understanding colorectal cancer.

Main Methods:

  • Literature review focusing on familial adenomatous polyposis (FAP).
  • Literature review focusing on juvenile polyposis (JP).
  • Literature review focusing on Peutz-Jeghers syndrome (PJS).

Main Results:

  • Detailed discussion of the genetic underpinnings of FAP, JP, and PJS.
  • Comprehensive overview of the clinical presentations and associated risks for each syndrome.
  • Emphasis on the shared pathways and genetic alterations relevant to sporadic colorectal cancer.

Conclusions:

  • Familial adenomatous polyposis, juvenile polyposis, and Peutz-Jeghers syndrome are key models for colorectal cancer research.
  • Understanding the molecular genetics and clinical features of these syndromes is vital for advancing cancer knowledge.
  • These hereditary conditions provide critical insights into the mechanisms of cancer initiation and progression.