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Updated: Jul 16, 2026

Transcutaneous Neuromuscular Electrical Stimulation for Treating Varicocele-Induced Scrotal Pain
Published on: August 30, 2024
Palmar-plantar erythrodysesthesia associated with scrotal and penile involvement with capecitabine
Christy M Sapp1, Philip DeSimone
1University of Kentucky, Markey Cancer Center, Lexington, KY 40536-0093, USA.
Abstract:
Capecitabine is an orally active fluoropyrimidine that has been approved for first-line treatment of metastatic colorectal cancer when fluoropyrimidines alone are indicated. One of the toxicities described in the literature associated with capecitabine is palmar-plantar erythrodysesthesia. Based on a careful review of the literature, no reported cases of erythema, ulceration, and swelling that involves the penis and scrotum have been described in association with capecitabine. The following 2 cases illustrate palmar-plantar erythrodysesthesia with scrotal and penile involvement secondary to capecitabine.
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