Gentamicin decreases guanylyl cyclase activity in rat glomerulus

Eun Hui Bae1, Yoon Wha Oh, Jeong Woo Park

  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Summary

Gentamicin (GM) causes kidney damage by altering nitric oxide (NO) and natriuretic peptide (NP) systems. This nephropathy is linked to reduced guanylyl cyclase activity in the glomerulus.

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