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Updated: Jul 16, 2026

In vitro Reconstitution of the Active T. castaneum Telomerase
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In vitro Reconstitution of the Active T. castaneum Telomerase

Published on: July 14, 2011

Telomerase: going beyond the ends

David De Semir1, Mehdi Nosrati, Shang Li

  • 1Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, Comprehensive Cancer Center, Department of Dermatology, University of California San Francisco, San Francisco, California 94115, USA.

Cell Cycle (Georgetown, Tex.)
|February 22, 2007
PubMed

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

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