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Orthotopic Aortic Transplantation: A Rat Model to Study the Development of Chronic Vasculopathy
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Orally administered rapamycin does not modify rat aortic vascular tone.

Milton de M Soares Neto1, Giovana S Di Marco, Dulce E Casarini

  • 1Department of Cardiology, Federal University of São Paulo, São Paulo, Brazil.

Journal of Cardiovascular Pharmacology
|February 22, 2007
PubMed
Summary

Oral rapamycin (RP) prevents restenosis after stenting. This study found that RP does not affect vascular tone in adult rat endothelial cells, suggesting it is safe for vascular function when administered orally.

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Area of Science:

  • Cardiovascular Biology
  • Pharmacology
  • Vascular Medicine

Background:

  • Rapamycin (RP) inhibits vascular smooth muscle cell proliferation and migration, reducing neointimal formation and in-stent restenosis.
  • High costs of RP-eluting stents limit widespread use.
  • Oral RP with bare metal stents is a cost-effective alternative for restenosis prevention, but potential effects on vascular tone require investigation.

Purpose of the Study:

  • To evaluate the effects of rapamycin (RP) on endothelium-dependent vascular tone.
  • To determine if oral administration of RP impacts the function of adult rat endothelial cells in vascular tone control.

Main Methods:

  • In vitro incubation of aortic rings with high concentrations of RP.
  • In vivo administration of RP to rats.
  • Assessment of vascular contraction and relaxation responses in aortic rings.

Main Results:

  • In vitro incubation with high RP concentrations did not alter aortic ring contraction or relaxation.
  • In vivo administration of RP also showed no significant effects on vascular tone.
  • These findings indicate that RP does not impair the function of adult, non-proliferative rat endothelial cells involved in vascular tone regulation.

Conclusions:

  • Orally administered rapamycin (RP) does not adversely affect endothelium-dependent vascular tone in adult rats.
  • This suggests that oral RP is a potentially safe and effective strategy for preventing restenosis without compromising normal vascular function.