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Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

Iron storage disease in tapirs.

Christopher J Bonar¹, John G Trupkiewicz, Barbara Toddes

¹Cleveland Metroparks Zoo, 3900 Wildlife Way, Cleveland, Ohio 44109, USA.

Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians

|February 23, 2007

Summary

Tapirs may be at risk for hemochromatosis, a condition of iron overload. A review of tapir necropsy reports found hemosiderosis and fatal hemochromatosis in two Baird's tapirs.

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Area of Science:

Veterinary Pathology
Zoological Medicine
Comparative Pathology

Background:

Previous studies suggested tapirs might be susceptible to hemochromatosis based on serum iron levels.
Hemochromatosis has not been a commonly reported cause of mortality in tapirs.

Observation:

This study analyzed necropsy records of Baird's tapir, Malayan tapir, and Brazilian tapir from 1902-1994 at the Philadelphia Zoological Garden.
Histological examination of 19 tapir cases revealed 12 instances of hemosiderosis.
Two Baird's tapirs (Tapirus bairdii) exhibited fatal hemochromatosis.

Findings:

Hemochromatosis was identified in multiple tapir species, including fatal cases in Baird's tapirs.
This condition has been previously documented in horses, rhinoceroses, and one Brazilian tapir.
Investigated dietary factors were inconclusive in explaining the incidence of hemosiderosis and hemochromatosis.

Implications:

Highlights the importance of considering hemochromatosis in tapir health assessments.
Suggests a need for further research into the pathogenesis and potential management of iron overload in tapirs.
Contributes to the understanding of comparative pathology for iron metabolism disorders in zoo-housed megafauna.