Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Reperfusion injury.

B J Zimmerman¹, D N Granger

¹Department of Physiology, Louisiana State University Medical Center, Shreveport.

The Surgical Clinics of North America

|February 1, 1992

Summary

Reperfusion of ischemic intestine causes significant injury through reactive oxygen metabolites and white blood cells. These factors trigger inflammation, leading to damage in blood vessels and tissues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Weaving: a reflection of life.

Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses·2002

Same author

Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide.

The Journal of experimental medicine·2001

Same author

Endothelial expression of vascular cell adhesion molecule-1 correlates with metastatic pattern in spontaneous melanoma.

Microcirculation (New York, N.Y. : 1994)·2001

Same author

Splanchnic ischaemia-reperfusion injury: mechanistic insights provided by mutant mice.

Acta physiologica Scandinavica·2001

Same author

Inducible nitric oxide synthase (iNOS) and regulation of leucocyte/endothelial cell interactions: studies in iNOS-deficient mice.

Acta physiologica Scandinavica·2001

Same author

MAdCAM mediates lymphocyte-endothelial cell adhesion in a murine model of chronic colitis.

American journal of physiology. Gastrointestinal and liver physiology·2001

Area of Science:

Gastroenterology
Immunology
Vascular Biology

Background:

Ischemic intestine injury is a significant clinical problem.
Reperfusion following ischemia can exacerbate tissue damage.

Purpose of the Study:

To elucidate the mechanisms of microvascular and parenchymal cell injury during intestinal reperfusion.

Main Methods:

Review of existing evidence on intestinal reperfusion injury.
Analysis of the roles of reactive oxygen species and polymorphonuclear leukocytes.

Main Results:

Reperfusion injury involves both microvascular and parenchymal cell damage.
Reactive oxygen metabolites and activated polymorphonuclear leukocytes are key mediators.
Xanthine oxidase initiates inflammatory cascades.
Leukocyte adherence and emigration contribute to endothelial barrier disruption.

Conclusions:

Intestinal reperfusion injury is a complex process mediated by oxidative stress and inflammatory cell infiltration.
Understanding these mechanisms is crucial for developing therapeutic strategies.

Related Experiment Videos