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Updated: Jul 16, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
[Acute renal failure in critically ill patients]
1Odense Universitetshospital, Anaestesiologisk-intensiv Afdeling V, Odense C. palle.toft@ouh.fyns-amt.dk
Ugeskrift for Laeger
|February 23, 2007
Summary
Acute renal failure (ARF) is a sudden decline in kidney function common in critically ill patients. Continuous renal replacement therapy (CRRT) is the preferred ICU treatment for ARF.
Area of Science:
- Nephrology
- Critical Care Medicine
- Renal Physiology
Context:
- Acute renal failure (ARF) affects 10-23% of critically ill patients.
- High mortality rate (50-70%) associated with ARF in ICU settings.
- ARF is characterized by elevated plasma creatinine and reduced urine output.
Purpose:
- To outline the causes, characteristics, and management of acute renal failure (ARF) in intensive care units (ICUs).
- To highlight the efficacy of continuous renal replacement therapy (CRRT) in managing ARF.
Summary:
- Key causes of ARF include hypovolemia, hypotension, sepsis, and nephrotoxic agents.
- Non-dialytic management involves early volume resuscitation; furosemide may exacerbate ARF.
- Continuous renal replacement therapy (CRRT) is the current standard of care for ARF in ICU patients.
Impact:
- CRRT offers a life-saving intervention for critically ill patients with ARF.
- Understanding ARF's causes and treatments can improve patient outcomes.
- Early recognition and appropriate management of ARF are crucial for survival and renal function recovery (90-95% if survived).
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