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Updated: Jul 16, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
Visual acuity and perimacular retinal layers detected by optical coherence tomography in patients with retinitis
Toshihiko Matsuo1, Noriko Morimoto
1Department of Ophthalmology, Faculty of Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama City 700-8558, Japan. matsuot@cc.okayama-u.ac.jp
Background:
The remaining retinal neurones or layered structure in the degenerating retina have been the prerequisite for epiretinal or subretinal retinal prostheses.
Aim:
To detect the layered structure in the eyes of patients with retinitis pigmentosa by optical coherence tomography.
Methods:
In a prospective non-comparative study, 115 eyes of 58 consecutive patients with retinitis pigmentosa underwent optical coherence tomography to obtain horizontal and vertical retinal cross-section images at the centre of the macula. The number of high-reflectance retinal layers, one, two or three layers, was tested to determine whether it correlates with best-corrected visual acuity.
Results:
The best-corrected visual acuity was significantly better in the eyes in which more retinal layers were detected (p<0.001, Kruskal-Wallis test, p<0.05, Tukey-Kramer test). The best-corrected visual acuity in the right eye and in the left eye was correlated with each other (p<0.001, Spearman rank correlation test) and decreased with age.
Conclusions:
Optical coherence tomography can be used to obtain information regarding the retinal layer structure in patients with retinitis pigmentosa, and may be used as a clinical test to assess the feasibility of retinal prostheses in future.
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