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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

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Related Experiment Video

Updated: Jul 16, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Fasting insulin modifies the relation between age and renal function.

Leendert H Oterdoom¹, Aiko P J de Vries, Ron T Gansevoort

¹Department of Medicine, University Medical Center Groningen, Hanzeplein 1, Postbus 30.001, 9700 RB Groningen, The Netherlands.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|February 23, 2007

Summary

High insulin levels accelerate age-related decline in kidney function among non-diabetics. This suggests insulin resistance contributes to end-stage renal disease incidence.

Related Experiment Videos

Last Updated: Jul 16, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Area of Science:

Nephrology
Endocrinology
Gerontology

Background:

Rising end-stage renal disease (ESRD) rates are linked to insulin resistance.
Insulin resistance and hyperinsulinemia may accelerate kidney function decline via glomerular hyperfiltration, even in non-diabetics.

Purpose of the Study:

To investigate if fasting insulin levels modify the age-related decline in renal function within a general non-diabetic population.

Main Methods:

Cross-sectional analysis of 3432 general population subjects.
Linear regression models assessed associations between age, renal function (creatinine clearance [CrCl], urinary albumin excretion [UAE]), and insulin modification.
Renal function measured via 24-h CrCl and 24-h UAE.

Main Results:

A parabolic relationship between age and renal function was confirmed.
Fasting insulin significantly modified these age-related renal function relationships (P < 0.001).
Hyperinsulinemia was associated with accelerated CrCl decline and increased UAE with aging.

Conclusions:

Insulin appears to hasten age-related renal function decline in the general non-diabetic population.
Insulin resistance and hyperinsulinemia may contribute to the rising incidence of ESRD.