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Updated: Jul 16, 2026

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
Published on: May 20, 2015
Caveolin-1 and liver regeneration: role in proliferation and lipogenesis
Philippe G Frank1, Michael P Lisanti
1Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Philippe.Frank@jefferson.edu
Abstract:
Caveolin-1 is an essential component of caveolae, which form 50-100 nm cell surface plasma membrane invaginations. Caveolin-1 has been previously implicated in the regulation of cellular proliferation and lipogenesis. Current data now suggest that caveolin-1 plays an essential role in the regulation of liver regeneration and that it is implicated in the regulation of triglyceride accumulation, which is an essential process that plays a critical role in the regulation of liver regeneration. These findings are consistent with the importance of a lipogenesis program in the regulation of liver regeneration.
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