Related Experiment Video
Updated: Jul 16, 2026
A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
[Off-line exhaled nitric oxide measurement in children]
S Hamouda1, B Chevalier-Bidaud, R Aboutaam
1Service de Pneumologie et Allergologie Pédiatriques, Hôpital Necker Enfants Malades, AP-HP, Paris.
Introduction:
The objective is to test the validity of a tool allowing an offline measurement of the fraction of expired nitric oxide (FENO). The device is a T-tube on which a pressure gauge allows the control of the expiratory flow and whose two side branches have a gauge such as the bags assembled on each one of them fill successively.
Methods:
The first phase aims to check that the sample collected in the second bag answers the criteria of analysis of NO during a single expiration and that this measurement can be delayed. The second phase aims to test the feasibility and the repeatability of the offline analysis in children.
Results:
The device makes it possible to stabilize the expiratory flow at 100 ml/s. The NO concentration in the second bag is stable during 6 hours. The intra measurement coefficient of variation of delayed FENO 0.1 is 7% (N = 19).
Conclusion:
A off line measurement of the exhaled nitric oxide is reliable in asthmatic children.
