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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...

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Updated: Jul 6, 2026

Bovine Mammary Gland Biopsy Techniques
14:53

Bovine Mammary Gland Biopsy Techniques

Published on: December 23, 2018

Pathogenesis and therapy of psoriasis.

Michelle A Lowes1, Anne M Bowcock, James G Krueger

  • 1Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, Box 178, New York, New York 10021, USA.

Nature
|February 23, 2007
PubMed
Summary

Psoriasis, a common genetic skin disease, involves keratinocyte abnormalities triggered by immune system activation. New therapies targeting these immune components offer hope for psoriasis and other inflammatory conditions.

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Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Psoriasis is a prevalent human skin condition with significant genetic factors.
  • It manifests as abnormal keratinocyte proliferation and differentiation.
  • Immune system activation, involving T cells and cytokines, is central to its pathogenesis.

Purpose of the Study:

  • To summarize the understanding of psoriasis pathogenesis.
  • To highlight the role of the immune system in psoriasis.
  • To discuss the implications of novel psoriasis therapies.

Main Methods:

  • Review of current scientific literature on psoriasis.
  • Analysis of the immunological pathways involved in psoriasis.
  • Evaluation of emerging therapeutic strategies.

Main Results:

  • Psoriasis involves genetic predisposition and immune dysregulation.
  • Keratinocyte hyperproliferation is a hallmark of the disease.
  • Immune cells, cytokines, and chemokines play critical roles.

Conclusions:

  • Psoriasis pathogenesis is complex, involving genetic and immune interactions.
  • Targeting immune pathways is a promising therapeutic approach for psoriasis.
  • These advancements may inform treatments for other inflammatory diseases.