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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
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Transplacental isopropanol exposure: case report and review of metabolic principles

J N Wood1, J Carney, K Szczepanski

  • 1Division of General Pediatrics, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. woodjo@email.chop.edu

Journal of Perinatology : Official Journal of the California Perinatal Association
|February 23, 2007
PubMed

Isopropanol, a known central nervous system depressant has been reported to cause toxicity via multiple routes including ingestion, inhalation and dermal exposure. We present a case of transplacental isopropanol exposure in a neonate. A woman reported polysubstance abuse in the 1 to 2 days before precipitously delivering a newborn infant. The neonate developed hypotension, hypotonia and seizure activity within the first few hours of life. Blood samples from the infant revealed toxic levels of isopropanol. Similar symptoms have been reported in infants with isopropanol toxicity from other routes of exposure.

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