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Updated: Jul 16, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Antibacterial diterpenoids from Sagittaria pygmaea

Xue-Ting Liu1, Yao Shi, Biao Yu

  • 1Department of Natural Medicinal Chemistry, China Pharmaceutical University, People's Republic of China.

Planta Medica
|February 23, 2007
PubMed
Summary

Five new diterpenoids were isolated from Sagittaria pygmaea. Compounds 2, 3, 4, and 5 demonstrated antibacterial activity against oral pathogens Streptococcus mutans and Actinomyces viscosus.

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Last Updated: Jul 16, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
08:20

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Area of Science:

  • Natural Products Chemistry
  • Medicinal Chemistry
  • Microbiology

Background:

  • Sagittaria pygmaea is a plant with potential medicinal properties.
  • Diterpenoids are a class of natural compounds with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new diterpenoids from Sagittaria pygmaea.
  • To evaluate the antibacterial activity of isolated compounds against oral pathogens.

Main Methods:

  • Isolation and purification of compounds using spectroscopic techniques (NMR, MS) and X-ray crystallography.
  • Determination of chemical structures and relative configurations.
  • Antibacterial activity assays using Minimum Inhibitory Concentration (MIC) determination.

Main Results:

  • Five new diterpenoids (1-5) were identified, including glycosylated ent-kauranes and isopimarane derivatives.
  • Compound 2 showed potent activity against Streptococcus mutans and Actinomyces viscosus (MIC = 15.6 μg/mL).
  • Compounds 3, 4, and 5 exhibited varying degrees of activity against these oral pathogens.

Conclusions:

  • Sagittaria pygmaea is a source of novel diterpenoids with significant antibacterial properties.
  • The isolated diterpenoids, particularly compound 2, show promise for development as agents against oral infections.
  • Further research into the mechanism of action and structure-activity relationships is warranted.