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Related Experiment Videos

Slow injection does not prevent midazolam-induced ventilatory depression.

C M Alexander1, L E Teller, J B Gross

  • 1Department of Anesthesiology, University of Pennsylvania School of Medicine, Philadelphia.

Anesthesia and Analgesia
|February 1, 1992
PubMed
Summary

Slow administration of midazolam does not prevent respiratory depression. Rapid IV midazolam initially caused more significant ventilatory depression, but effects were similar after infusion completion.

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Area of Science:

  • Anesthesiology
  • Pharmacology
  • Respiratory Physiology

Background:

  • Midazolam is a common anesthetic agent.
  • Ventilatory depression is a known side effect of midazolam.
  • The influence of administration rate on midazolam's respiratory effects requires clarification.

Purpose of the Study:

  • To investigate if the rate of intravenous midazolam administration impacts the risk of midazolam-induced ventilatory depression.
  • To compare the effects of rapid versus slow midazolam infusion on hypercarbic ventilatory response.

Main Methods:

  • Ten healthy volunteers received intravenous midazolam (0.1 mg/kg).
  • Midazolam was administered either rapidly (over 15 seconds) or slowly (over 5 minutes).
  • The hypercarbic ventilatory response (ventilatory response to CO2) was measured.

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Main Results:

  • Rapid midazolam administration caused significantly greater initial depression of the ventilatory response to CO2 compared to slow administration.
  • After the infusion period (5-20 minutes), the degree of CO2 response depression was similar regardless of administration rate.
  • Minute ventilation and tidal volume decreased more rapidly with fast infusion but showed no significant difference between groups after the slow infusion was completed.

Conclusions:

  • Slow intravenous administration of midazolam does not independently protect against respiratory depression.
  • The rate of midazolam administration primarily affects the onset, not the overall magnitude, of ventilatory depression.