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Pharmacotherapy for microscopic colitis.

Geoffrey C Wall1, Lori L Schirmer, Michael J Page

  • 1Department of Pharmacy, Iowa Methodist Medical Center, and College of Pharmacy and Health Sciences, Drake University, Des Moines, Iowa 50311-4505, USA. geoff.wall@drake.edu

Pharmacotherapy
|February 24, 2007
PubMed
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Microscopic colitis, a cause of chronic diarrhea, can be treated with medication. While bismuth subsalicylate is a cost-effective first option, budesonide offers superior effectiveness for achieving remission in microscopic colitis patients.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Microscopic colitis is a prevalent condition causing chronic watery diarrhea.
  • The exact cause of microscopic colitis remains unknown, but certain medications like NSAIDs, aspirin, and lansoprazole are potential risk factors.
  • Current therapeutic strategies focus on symptom management.

Purpose of the Study:

  • To review and synthesize evidence on the pharmacotherapy for microscopic colitis.
  • To evaluate the effectiveness and suitability of different treatment options.

Main Methods:

  • A comprehensive literature search was conducted using MEDLINE and International Pharmaceutical Abstracts.
  • Bibliographies of key articles were reviewed to identify relevant primary English-language reports.
  • The review focused on treatment accounts for microscopic colitis.

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Main Results:

  • Pharmacotherapy can effectively treat microscopic colitis.
  • Budesonide demonstrates the strongest evidence for efficacy in reducing stool volume/frequency and improving quality of life.
  • Antidiarrheals and bismuth subsalicylate are cost-effective initial choices, but budesonide may be necessary for remission.

Conclusions:

  • Microscopic colitis is a treatable condition through pharmacotherapy.
  • Bismuth subsalicylate and antidiarrheals are reasonable first-line options due to cost and side effect profiles.
  • Budesonide is a highly effective, though costly, option for patients requiring more intensive treatment to achieve remission.