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Published on: May 6, 2018
Encephalopathy after furosemide use in nephrotic syndrome
Ajay P Sharma1, Joanne Grimmer
1Department of Pediatrics, University of Western Ontario, London, Ontario, Canada. ajay.sharma@lhsc.on.ca
Abstract:
An 18-year-old girl with nephrotic syndrome presented with a life-threatening respiratory failure and a severe encephalopathy, shortly after being started on furosemide. The evaluation confirmed furosemide as the sole culprit for the clinical manifestations. This case highlights an unpredictable dose-response relationship of furosemide. The pathophysiological basis, differential diagnosis and clinical implications of the observed findings are discussed.
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