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Related Experiment Video

Updated: Jul 16, 2026

Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome

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Published on: May 26, 2023

Bolus or continuous hydrocortisone--that is the question.

Steffen Weber-Carstens¹, Didier Keh

¹Clinic of Anesthesiology and Intensive Care Medicine, Charité, Universitätsmedizin Berlin, Campus Virchow-Klinikum & Campus Mitte, Berlin, Germany. steffen.weber-carstens@charite.de

Critical Care (London, England)

|February 24, 2007

Summary

Continuous hydrocortisone infusion in septic shock reduces hyperglycemia compared to bolus dosing, improving patient outcomes and easing staff workload. This finding is crucial for optimizing sepsis management strategies.

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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

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Published on: January 31, 2022

Area of Science:

Critical Care Medicine
Endocrinology
Pharmacology

Background:

Sepsis management involves evolving guidelines from randomized controlled trials.
Combining treatments like intensive insulin therapy and hydrocortisone in septic shock can lead to harmful interactions, such as steroid-induced hyperglycemia complicating glycemic control.

Discussion:

Loisa and coworkers investigated the interaction between hydrocortisone administration and glycemic control in septic shock.
The study compared continuous hydrocortisone infusion with bolus application to mitigate adverse effects.

Key Insights:

Continuous hydrocortisone infusion was associated with fewer hyperglycemic episodes compared to bolus administration.
Continuous infusion also led to a reduced staff workload, indicating a more efficient treatment method.

Outlook:

Further research should explore optimal hydrocortisone administration strategies in sepsis.
These findings may inform updated clinical guidelines for managing septic shock and its associated metabolic derangements.