Synthetic N-pyridinyl(methyl)-indol-3-ylpropanamides as new potential immunosuppressive agents
Delphine Carbonnelle1, Morgane Lardic, Alexandra Dassonville
1Nantes University, Nantes Atlantique Universities, Immuno-Pharmacology Department, BioCiT, UPRES EA 1155, Faculty of Pharmacy, 1 rue Gaston Veil, Nantes, France.
Abstract:
Several N-pyridinyl(methyl)-indol-3-ylpropanamides were synthesized and pharmacological evaluations of their immunosuppressive potential were performed. Among thirteen compounds tested in vitro on murine T proliferation, three showed interesting inhibiting activity. For the most active compound (propanamide 18), immunosuppressive activity was documented both in vitro on human T lymphocytes proliferation and in vivo on mice delayed-type hypersensitivity. These experimental data demonstrated that these compounds hold potential as immunosuppressive agents.
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