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Updated: Jul 16, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp
Hyi-Seung Lee1, Tae-Hoon Lee, Seung Hwan Yang
1Marine Natural Products Laboratory, Korea Ocean Research and Development Institute, Ansan PO Box 29, Seoul 425-600, Republic of Korea.
Abstract:
Two sesterterpene sulfates (1-2) were isolated from tropical sponge Hippospongia sp. and their inhibitory activities against isocitrate lyase (ICL) from the rice blast fungus Mgnaporthe grisea were evaluated. Compound 3 was obtained by hydrolysis of compound 1. Compounds 1 and 3 were found to be potent ICL inhibitors, which inhibited appressorium formation and C(2) carbon utilization in M. grisea. Our results suggest that ICL plays crucial role in appressorium formation of M. grisea and is a new target for the protection of rice blast disease.
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