Jove
Visualize
Contact Us

Related Experiment Videos

The pattern visual evoked potential and pattern electroretinogram in drusen-associated optic neuropathy.

G B Scholl1, H S Song, D E Winkler

  • 1Department of Neurology, Massachusetts General Hospital, Boston 02114.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|January 1, 1992
PubMed
Summary

Optic disc drusen commonly impair optic nerve function, affecting visual fields and electrophysiologic tests. Pattern electroretinography reveals ganglion cell dysfunction, primarily through N95 component abnormalities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A case of primary bone lymphoma with nervous system symptoms as initial manifestation].

Zhonghua nei ke za zhi·2021
Same author

Risk Factors that Predict Levothyroxine Medication after Thyroid Lobectomy.

Acta endocrinologica (Bucharest, Romania : 2005)·2021
Same author

Clinical results of treatment of garden type 1 and 2 femoral neck fractures in patients over 70-year old.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2015
Same author

In vivo time-sequential histological study focused on melanocytes: suggestion of golden time for intervention to prevent post-laser pigmentary changes.

Journal of the European Academy of Dermatology and Venereology : JEADV·2015
Same author

Cytochalasin B inhibits the proliferation of human glioma U251 cells through cell cycle arrest and apoptosis.

Genetics and molecular research : GMR·2014
Same author

Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels.

Genetics and molecular research : GMR·2013
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Optic disc drusen are abnormal calcifications within the optic nerve head.
  • Their impact on optic nerve conduction and retinal function requires further elucidation.

Purpose of the Study:

  • To prospectively evaluate clinical and electrophysiologic evidence of optic nerve conduction impairment in patients with optic disc drusen.

Main Methods:

  • Prospective study of 16 patients (29 eyes) with optic disc drusen.
  • Clinical assessments included visual acuity, kinetic visual fields, and Farnsworth-Munsell 100-Hue testing.
  • Electrophysiologic tests comprised flash visual evoked potentials (FVEP), pattern visual evoked potentials (PVEP), and pattern electroretinograms (PERG).

Main Results:

Related Experiment Videos

  • Abnormalities were frequent: visual acuity (28%), kinetic visual field (76%), Farnsworth-Munsell 100-Hue (41%), and FVEP (54%).
  • PVEP showed prolonged P100 latency in 41% of eyes.
  • PERG analysis revealed reduced P50 amplitude (17%) and, most commonly, reduced or absent N95 component (79%), indicating ganglion cell dysfunction.

    • Conclusions:

    • Optic disc drusen are associated with significant optic nerve dysfunction, particularly affecting visual fields and electrophysiologic responses.
    • The pattern electroretinogram's N95 component is a sensitive indicator of ganglion cell dysfunction in this condition.
    • Findings support distinct retinal origins for P50 and N95 components in PERG.