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Updated: Jul 16, 2026

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing
Published on: February 13, 2016
A simplified circuit of modified ultrafiltration.
Shiv Kumar Choudhary1, Sachin Talwar, Balram Airan
1Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, India. shivchoudhary@hotmail.com
A simplified circuit for modified ultrafiltration (MUF) is presented. This cost-effective technique enhances safety during cardiopulmonary bypass (CPB) by reducing air embolism risks and allowing emergency re-institution of bypass.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Medical Devices
Background:
- Conventional ultrafiltration (CUF) and modified ultrafiltration (MUF) are critical procedures in cardiopulmonary bypass (CPB).
- Existing circuits may require complex manipulations and pose risks like air embolism.
Purpose of the Study:
- To describe a simplified circuit for modified ultrafiltration (MUF).
- To highlight the advantages of this simplified MUF circuit in terms of safety, cost, and versatility.
Main Methods:
- A novel, simplified circuit design for MUF is detailed.
- The circuit allows seamless transition between CUF and MUF with minimal intervention.
Main Results:
- The described MUF technique is simple and inexpensive.
- It reduces the risk of air embolism and air cavitation.
- The circuit facilitates emergency re-institution of cardiopulmonary bypass (CPB).
- The technique is applicable to both adult and pediatric patients.
Conclusions:
- The simplified MUF circuit offers a safe, efficient, and cost-effective alternative for ultrafiltration during CPB.
- This innovation enhances patient safety and procedural flexibility in cardiac surgery.
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