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Updated: Jul 16, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Psychological morbidity following miscarriage.

Ingrid H Lok¹, Richard Neugebauer

¹Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. ingridlok@cuhk.edu.hk

Best Practice & Research. Clinical Obstetrics & Gynaecology

|February 24, 2007

Summary

Miscarriage can lead to significant psychological distress, including anxiety and depression, affecting up to 50% of women. Effective screening and intervention studies are needed to support women after pregnancy loss.

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Last Updated: Jul 16, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Area of Science:

Reproductive Health
Mental Health
Psychology

Background:

Miscarriage is linked to substantial and potentially long-lasting psychological consequences.
Up to 50% of women experience psychological morbidity post-miscarriage, including grief, anxiety, and depression.
Symptoms can persist for 6-12 months, with risk factors including prior loss and lack of support.

Purpose of the Study:

To review the psychological impact of miscarriage.
To identify risk factors for psychological morbidity after miscarriage.
To highlight the need for better screening and intervention strategies.

Main Methods:

Literature review of emerging evidence on psychological consequences of miscarriage.
Analysis of reported prevalence of psychological morbidity (grief, anxiety, depression).
Identification of predisposing risk factors and moderating clinical factors.

Main Results:

Significant psychological morbidity affects up to 50% of women after miscarriage.
Common symptoms include grief, anxiety, and depression, with major depressive disorder in 10-50%.
Risk factors identified; clinical practices may moderate impact; screening tools are lacking.

Conclusions:

Miscarriage has a profound psychological impact, necessitating better support.
There is a lack of established screening measures and randomized controlled intervention studies.
Psychological follow-up is desired, indicating a need for evidence-based interventions.