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Paget's disease: current concepts
1Department of Medicine, University of Sydney, New South Wales, Australia.
Abstract:
The curious geographic variations in the prevalence of Paget's disease remain unexplained and the viral hypothesis remains unproved. An association between transient hyperphosphataemia of infancy and subsequent Paget's disease has not been established. Some 5% of Pagetic patients have hyperparathyroidism although the mechanism of this apparent association remains unknown. Several agents are available for the medical treatment of Paget's disease but there is a lack of consensus concerning therapeutic aims.
Insights
The geographic variations and viral causes of Paget's disease are unknown. Current treatments for Paget's disease lack consensus on therapeutic goals.
Area of Science:
- Bone Metabolism and Disease
- Epidemiology of Skeletal Disorders
Background:
- Geographic variations in Paget's disease prevalence are unexplained.
- The viral hypothesis for Paget's disease etiology remains unproven.
- An association between infantile hyperphosphataemia and Paget's disease is not established.
Purpose of the Study:
- To review the current understanding of Paget's disease etiology and epidemiology.
- To discuss the association between Paget's disease and hyperparathyroidism.
- To evaluate the available medical treatments for Paget's disease and therapeutic goals.
Main Methods:
- Literature review of studies on Paget's disease.
- Analysis of epidemiological data.
- Discussion of clinical associations and treatment options.
Main Results:
- Paget's disease etiology, including geographic variations and viral links, is not understood.
- The connection between transient hyperphosphataemia of infancy and Paget's disease requires further investigation.
- Hyperparathyroidism is observed in approximately 5% of Paget's disease patients, with an unclear mechanism.
Conclusions:
- The etiology of Paget's disease remains largely unknown.
- Further research is needed to elucidate the causes and associations of Paget's disease.
- Consensus on optimal therapeutic aims for Paget's disease treatment is lacking.