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Related Experiment Video

Updated: May 26, 2026

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

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Interleukin-18 in chronic joint diseases.

A P N Lotito¹, C A A Silva, S B V Mello

¹Department of Paediatrics, University of Sao Paulo, Brazil. paolalotito@ig.com.br

Autoimmunity Reviews

|February 24, 2007

Summary

Interleukin-18 (IL-18) plays a key role in inflammatory joint diseases like rheumatoid arthritis. This study summarizes research on IL-18

Area of Science:

Immunology
Rheumatology
Cytokine Biology

Background:

Interleukin-18 (IL-18) is a pro-inflammatory cytokine within the IL-1 superfamily.
IL-18 exhibits potent Th1-promoting activities, often in conjunction with IL-12.

Purpose of the Study:

To investigate the role of IL-18 in inflammatory joint diseases.
To summarize in vivo and in vitro studies on IL-18's impact on the arthritic process.
To elucidate IL-18's function within the network of inflammatory mediators.

Main Methods:

Review and synthesis of existing in vivo and in vitro studies.
Analysis of IL-18's pro-inflammatory actions in arthritis models.
Examination of IL-18's interactions within the cytokine network.

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Main Results:

IL-18 is implicated in the pathogenesis of rheumatoid arthritis, adult onset Still's disease, and juvenile idiopathic arthritis.
Evidence highlights IL-18's contribution to the inflammatory cascade in arthritic conditions.
IL-18 participates in a complex interplay with other mediators driving joint inflammation.

Conclusions:

Interleukin-18 is a significant factor in the development and progression of inflammatory joint diseases.
Targeting IL-18 may offer therapeutic potential for conditions like rheumatoid arthritis.
Further research into IL-18's network interactions is warranted for comprehensive understanding.