Related Experiment Video
Updated: Jul 16, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
Published on: December 10, 2021
Regulation of Wnt signalling by receptor-mediated endocytosis
Akira Kikuchi1, Hideki Yamamoto
1Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. akikuchi@hiroshima-u.ac.jp
Abstract:
Wnts compromise a large family of secreted and hydrophobic glycoproteins that control a variety of developmental and adult processes in all metazoan organisms. Recent advances in the field of Wnt signalling have revealed that Wnt activates multiple intracellular cascades, resulting in the regulation of cellular proliferation, differentiation, migration and polarity. However, it is not clear how Wnt activates these pathways after it binds to the receptors. It has been shown that Wnt and its antagonist Dickkopf are internalized with their receptors. This review highlights distinct endocytic pathways correlate with specificity of Wnt signalling events.
Related Concept Videos
Non-Canonical Wnt Signaling Pathways
Non-Canonical Wnt Signaling Pathways
Canonical Wnt Signaling Pathway
Canonical Wnt Signaling Pathway
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
Receptor-mediated Endocytosis
